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Merck - 23-048M - Parkin Protein, active, 250 µg

  • MFR SKU: 23-048M
  • ITEM #: 11574873
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ITEM #: 11574873
Active, full length, human recombinant human Parkin. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Merck - 23-048M - Parkin Protein, active, 250 µg

  • Item #: 11574873
  • MFR SKU: 23-048M
  • Catalogue Number 23-048M
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • Parkin Protein, active, 250 µg
  • Alternate Names
  • Parkinson juvenile disease protein 2
  • PARK2
  • PRKN
  • Background Information Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the -synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.
  • Quality Level MQ300
  • Application Active, full length, human recombinant human Parkin. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
  • Key Applications
  • Enzyme Assays
  • Cascade Component E3
  • Entrez Gene Number
  • NM_004562
  • Purification Method Purified using immobilized metal affinity chromatography.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 250 µg

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