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Merck - 23-054 - MuRF1 Protein, active, 10 µg

  • MFR SKU: 23-054
  • ITEM #: 11574885
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ITEM #: 11574885
Active, full length, recombinant human MuRF1. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Merck - 23-054 - MuRF1 Protein, active, 10 µg

  • Item #: 11574885
  • MFR SKU: 23-054
  • Catalogue Number 23-054
  • Brand Family Upstate
  • Trade Name
  • Upstate
  • MuRF1 Protein, active, 10 µg
  • Alternate Names
  • E3 ubiquitin-protein ligase TRIM63
  • Iris RING finger protein (IRF)
  • Muscle-specific RING finger protein 1
  • RING finger protein 28 (RNF28)
  • Striated muscle RING zinc finger protein (SMRZ)
  • Background Information Muscle atrophy is a debilitating and life threatening disorder. It is associated with a number of diseases including cancer, diabetes, chronic obstructive pulmonary disease and AIDS and is a natural consequence of inactivity and aging. MuRF1 is an E3 ubiquitin ligase which has been implicated as a component of atrophy-associated proteolysis. It contains an amino terminal RING finger that mediates ubiquitin transfer along with a zinc finger and two coiled-coil domains in its central region. It is up-regulated in a number of different models of atrophy and interacts with numerous myofibrillar proteins as well as Cardiac Troponin I and Creatine Kinase. Deletion of MuRF1 in mice has been shown to inhibit skeletal muscle atrophy suggesting that it may be an important drug target for the prevention of muscle wasting.
  • Quality Level MQ300
  • Application Active, full length, recombinant human MuRF1. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
  • Key Applications
  • Enzyme Assays
  • Cascade Component E3
  • Entrez Gene Number
  • NM_032588
  • Purification Method Purified using glutathione sepharose.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Material Size 10 µg

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