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Merck - 23-060 - Ikk

  • MFR SKU: 23-060
  • ITEM #: 11574898
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ITEM #: 11574898
Catalogue Number 23-060
Brand Family Upstate
Trade Name
  • Upstate

IKKγ
Alternate Names
  • NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • FIP-3
  • NEMO
  • IKKg

Background Information IKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their...
ITEM #: 11574898
Catalogue Number 23-060
Brand Family Upstate
Trade Name
  • Upstate

IKKγ
Alternate Names
  • NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • FIP-3
  • NEMO
  • IKKg

Background Information IKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
Quality Level MQ100
Key Applications
  • Enzyme Assays

Cascade Component Substrate
Entrez Gene Number
  • AF091453

Purification Method Purified using glutathione sepharose.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Material Size 10 µg
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Merck - 23-060 - Ikk

  • Item #: 11574898
  • MFR SKU: 23-060
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