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Merck - 250255-1MG - Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

MFR SKU: 250255-1MG

ITEM #: 3441667

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ITEM #: 3441667
Cytochalasin D, Zygusporium mansonii^ 1mg white solid. Purity>=98% by TLC. Soluble in CHCl3. CAS 22144-77-0. M.W.: 507.6. Cell-permeable fungal toxin. 10-fold more potent than cytochalasin B in inhibiting actin filament function. Doesn't inhibit monosaccharide transport across cell membranes.
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Merck - 250255-1MG - Cytochalasin D, <i> Zygosporium mansonii</i> - CAS 22144-77-0 - Calbiochem

Item #: 3441667

MFR SKU: 250255-1MG

Technical Specs

Overview Cell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K + channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca 2+ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776 ).
Catalogue Number 250255
Brand Family Calbiochem®
References Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
CAS number 22144-77-0
ATP Competitive N
Form White solid
Hill Formula CHNO
Chemical formula CHNO
Reversible N
Structure formula Image
Quality Level MQ100
Primary Target Actin filament function

Purity ≥ 98% by TLC
Cell permeable Y
RTECS GZ4850000
R Phrase R: 26/27/28-61
Very toxic by inhalation, in contact with skin and if swallowed.
May cause harm to the unborn child.
S Phrase S: 3/7/9-22-36/37/39-45
Keep container tightly closed, in a cool well ventilated place.
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20° C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20° C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20° C.

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