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Merck - 260960-10MG - DNA-PK Inhibitor (DNAPK) | CAS 20357-25-9 | Calbiochem | 10MG

  • MFR SKU: 260960-10MG
  • ITEM #: 6281293
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ITEM #: 6281293
The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 10 mg Plastic ampoule

Merck - 260960-10MG - DNA-PK Inhibitor (DNAPK) | CAS 20357-25-9 | Calbiochem | 10MG

  • Item #: 6281293
  • MFR SKU: 260960-10MG
  • Overview A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC 50 = 15 µ M) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120 ). Does not affect PKC or Chk2 kinase activities.
  • Catalogue Number 260960
  • Brand Family Calbiochem®
  • Synonyms DMNB, 4, 5- D i m ethoxy-2- n itro b enzaldehyde, DNA-Dependent Protein Kinase Inhibitor
  • References Willmore, E., et al. 2004. Blood , 103, 4659.
  • Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.
  • CAS number 20357-25-9
  • ATP Competitive N
  • Form Bright Yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target DNA-PK activity 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 15 µ M against DNA-PK (DNA-dependent protein kinase) activity
  • Purity ≥ 90% by GC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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