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Merck - 260961-5MG - DNA-PK Inhibitor II (DNAPK) | CAS 154447-35-5 | Calbiochem | 5MG

  • MFR SKU: 260961-5MG
  • ITEM #: 6281358
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ITEM #: 6281358
DNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).
This listing is for 5 mg Plastic ampoule

Merck - 260961-5MG - DNA-PK Inhibitor II (DNAPK) | CAS 154447-35-5 | Calbiochem | 5MG

  • Item #: 6281358
  • MFR SKU: 260961-5MG
  • Overview A cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC 50 of 0.23 µ M. It is highly selective towards DNA-PK over PI3K-related kinases (IC 50 = 13 µ M for PI 3-K and > 100 µ M for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR.
  • Catalogue Number 260961
  • Brand Family Calbiochem®
  • Synonyms NU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
  • References Willmore, E., et al. 2004. Blood , 103, 4659.
  • Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
  • Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
  • Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
  • CAS number 154447-35-5
  • ATP Competitive Y
  • Form Crystalline solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Application DNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).
  • Primary Target DNA-PK 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.23 µ M against DNA-PK
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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