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Merck - 260964-5MG - DNA-PK Inhibitor V (DNAPK) | CAS 404009-46-7 | Calbiochem | 5MG

  • MFR SKU: 260964-5MG
  • ITEM #: 6280239
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ITEM #: 6280239
The DNA-PK Inhibitor V, also referenced under CAS 404009-46-7, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
This listing is for 5 mg Plastic ampoule

Merck - 260964-5MG - DNA-PK Inhibitor V (DNAPK) | CAS 404009-46-7 | Calbiochem | 5MG

  • Item #: 6280239
  • MFR SKU: 260964-5MG
  • Overview A morpholino-benzophenone compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC 50 = 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC 50 = 32 µ M, 3.7 µ M, 22 µ M and ~ 100 µ M for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50 µ M.
  • Catalogue Number 260964
  • Brand Family Calbiochem®
  • Synonyms AMA37, A ryl M orpholine A nalog 37, 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone
  • References Knight, Z.A., et al. 2004. Bioorg. Med. Chem. 12, 4749.
  • Willmore, E., et al. 2004. Blood , 103, 4659.
  • CAS number 404009-46-7
  • ATP Competitive Y
  • Form Yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target DNA-PK 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 270 nM against DNA-PK
  • Purity ≥ 95% by HPLC
  • Cell permeable N
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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