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Merck - 262017-10MG - APE1 Inhibitor III | Calbiochem | 10 MG

  • MFR SKU: 262017-10MG
  • ITEM #: 11574933
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ITEM #: 11574933
The APE1 Inhibitor III controls the biological activity of APE1. This small molecule/inhibitor is primarily used for Cell Structure applications.
This listing is for 10 mg

Merck - 262017-10MG - APE1 Inhibitor III | Calbiochem | 10 MG

  • Item #: 11574933
  • MFR SKU: 262017-10MG
  • Overview A cell-permeable benzothiazolyltetrahydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC 50 = 2.0 µ M in a fluorescence based HTS assay; and 12 .0 µ M in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC 50 = 600 nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t 1/2 = 80 min).
  • Catalogue Number 262017
  • Brand Family Calbiochem®
  • Synonyms Apurinic Endonuclease 1 Inhibitor III, Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III, N-(3-(1, 3-Benzo[d]thiazol-2-yl)-6-isopropyl-4, 5, 6, 7-tetrahydrothieno[2, 3-c]pyridin-2-yl)acetamide
  • References Rai, G., et al. 2012. J. Med. Chem. 55, 3101.
  • Form Brown solid
  • Hill Formula CHNOS
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target APE1
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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