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Merck - 264150-1MG - Caspase-3 Substrate IV, Fluorogenic (Z-DEVD-AFC) | CAS 1177935-21-5 | Calbiochem | 1 MG

  • MFR SKU: 264150-1MG
  • ITEM #: 3042474
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ITEM #: 3042474
Caspase-3 Substrate IV, Fluorogenic^ (Z-DEVD-AFC; Z-Asp-Glu-Val-Asp-AFC). Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Purity: >=97% by HPLC. Soluble in DMSO. FW: 821.7. Off-white solid, 1mg.
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Merck - 264150-1MG - Caspase-3 Substrate IV, Fluorogenic (Z-DEVD-AFC) | CAS 1177935-21-5 | Calbiochem | 1 MG

  • Item #: 3042474
  • MFR SKU: 264150-1MG
  • Overview Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
  • Catalogue Number 264150
  • Brand Family Calbiochem®
  • Synonyms Z-DEVD-AFC
  • References Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
  • Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
  • Kluck, R.M., et al. 1997. Science 275, 1132.
  • Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
  • Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
  • Nicholson, D.W., et al. 1995. Nature 376, 37.
  • CAS number 1177935-21-5
  • ATP Competitive N
  • Form White or off-white solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Fluorogenic caspase-3 substrate.
  • Purity ≥ 95% by HPLC
  • Cell permeable N
  • Emission max.
  • Excitation max.
  • Peptide Sequence Z-Asp-Glu-Val-Asp-AFC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for 3 months at -20° C.

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