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Merck - 266788-5MG - Diacylglycerol Kinase Inhibitor II (DAG ) | CAS 120166-69-0 | Calbiochem | 5MG

  • MFR SKU: 266788-5MG
  • ITEM #: 6280613
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ITEM #: 6280613
Diacylglycerol Kinase Inhibitor II^ ( {R59949; 3-{2-[4-(bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2, 3-dihydro-2-thioxo-4(1H)quinazolinone}). White to off-white solid. Inhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM).
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Merck - 266788-5MG - Diacylglycerol Kinase Inhibitor II (DAG ) | CAS 120166-69-0 | Calbiochem | 5MG

  • Item #: 6280613
  • MFR SKU: 266788-5MG
  • Overview Inhibits diacylglycerol kinase in isolated platelet membranes (IC 50 = 300 nM) and in intact platelets (IC 50 = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785 ).
  • Catalogue Number 266788
  • Brand Family Calbiochem®
  • Synonyms R59949, 3-{2-[4-[ bis -(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2, 3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
  • References Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
  • Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
  • Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
  • de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
  • CAS number 120166-69-0
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHFNOS
  • Chemical formula CHFNOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Diacylglycerol Kinase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot, flush with an inert gas and freeze at -20° C. Stock solutions are stable for up to 6 months at -20° C.

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