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Merck - 287815-10MG - 3, 4-Dichloroisocoumarin | CAS 51050-59-0 | Calbiochem | 10MG

  • MFR SKU: 287815-10MG
  • ITEM #: 3441807
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ITEM #: 3441807
3, 4-Dichloroisocoumarin^ A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Purity: >99% by elemental analysis. Soluble in DMF and DMSO. CAS: 51050-59-0. FW: 215.0. White solid, 10mg.
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Merck - 287815-10MG - 3, 4-Dichloroisocoumarin | CAS 51050-59-0 | Calbiochem | 10MG

  • Item #: 3441807
  • MFR SKU: 287815-10MG
  • Overview A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
  • Effective concentration: 5-100 µ M; t ½ = 20 min at pH 7.5.
  • Catalogue Number 287815
  • Brand Family Calbiochem®
  • References Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
  • Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
  • Odake, S., et al. 1991. Biochemistry 30, 2217.
  • Harper, J.W., et al. 1985. Biochemistry 24, 1831.
  • CAS number 51050-59-0
  • ATP Competitive N
  • Form White lyophilized solid
  • Hill Formula CHClO
  • Chemical formula CHClO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target serine proteases 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 5-100 µ M
  • Purity ≥ 99% by elemental analysis
  • Cell permeable N
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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