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Merck - 310500-5MG - D-erythro-Sphingosine, N, N-Dimethyl- - CAS 119567-63-4 - Calbiochem

  • MFR SKU: 310500-5MG
  • ITEM #: 3441315
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ITEM #: 3441315
D-erythro-Sphingosine, N, N-Dimethyl-^ Clear oil. Inhibits protein kinase C (IC50 = 12 mM) and stimulates src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells.
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Merck - 310500-5MG - D-<i>erythro</i>-Sphingosine, N, N-Dimethyl- - CAS 119567-63-4 - Calbiochem

  • Item #: 3441315
  • MFR SKU: 310500-5MG
  • Overview A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC 50 = 12 µ M) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
  • Catalogue Number 310500
  • Brand Family Calbiochem®
  • Synonyms DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
  • References Cuvillier, O., et al. 1996. Nature 381, 800.
  • Ohta, H., et al. 1995. Cancer Res. 55, 691.
  • Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
  • Hanada, K., et al. 1991. Biochemistry 30, 11682.
  • Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
  • CAS number 119567-63-4
  • ATP Competitive N
  • Form Waxy solid/Clear oil
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target PKC 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 12 µ M against PKC
  • Purity ≥ 98% by TLC
  • Cell permeable Y
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 weeks at -20° C.

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