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Merck - 322326-1MG - Diphtheria Toxin, Unnicked, Corynebacterium diphtheriae - Calbiochem

MFR SKU: 322326-1MG

ITEM #: 3441668

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ITEM #: 3441668
Diphtheria Toxin, Unnicked, Corynebacterium diphtheriae^ Solid lyophilized from sterile 10 mM Tris, 1 mM EDTA, pH 7.5. Catalyzes ADP-ribosylation of eukaryotic aminoacyltransferase II (EF2) using NAD as substrate, thereby inhibiting protein synthesis. May also induce internucleosomal breakdown.
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Merck - 322326-1MG - Diphtheria Toxin, Unnicked, <i>Corynebacterium diphtheriae</i> - Calbiochem

Item #: 3441668

MFR SKU: 322326-1MG

Technical Specs

Overview Catalyzes ADP-ribosylation of eukaryotic aminoacyltransferase II (EF2) using NAD as substrate, thereby inhibiting protein synthesis. May also induce internucleosomal breakdown. Causes DNA fragmentation and cytolysis in U937 cells. Activation requires nicking with a protease followed by reduction with DTT.
Catalogue Number 322326
Brand Family Calbiochem®
References Kochi, S.K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.
Chang, M.P., et al. 1989. J. Biol. Chem. 264, 15261.
Pappenheimer, A.M., Jr. 1977. Annu. Rev. Biochem. 46, 69.
Ittelson, T.R., and Gill, D.M. 1973. Nature 242, 330.
Uchida, T., et al. 1973. J. Biol. Chem. 248, 3851.
Pappenheimer, A.M., et al. 1972. Immunochem. 9, 891.
Uchida, T., et al. 1972. Science 175, 901.
Bowman, C.G., and Bonventre, P.F. 1970. J. Exp. Med. 131, 659.
Baseman, J.B., et al. 1970. J. Exp. Med. 132, 1138.
Gill, D.M., et al. 1969. J. Exp. Med. 129, 1.
Gill, D.M., et al. 1969. Cold Spring Harbor Symp. Quant. Biol. 34, 589.
Honjo, J., et al. 1968. J. Biol. Chem. 243, 3553.
ATP Competitive N
Form Solid
Formulation Lyophilized from sterile 10 mM Tris, 1 mM EDTA, pH 7.5.

Reversible N
Quality Level MQ100
Biological activity Note: Toxicity may vary by lot of toxin. Each laboratory should determine the optimum dosage for each particular application.
Primary Target Eukaryotic aminoacyltransferase II (EF2)
Purity Major band (under reducing conditions) of ~63 kDa
Cell permeable N
RTECS XW5807200
R Phrase R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.
S Phrase S: 36
Wear suitable protective clothing.
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2° C to +8° C
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot, quickly freeze on dry ice, and freeze (-70° C). Subsequent thawing should be carried out only at room temperature. For assays employing very low concentrations of diphtheria toxin, the use of a carrier protein, such as BSA or HSA, is recommended.

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