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Merck - 322337-2MG - Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 | Calbiochem | 2MG

  • MFR SKU: 322337-2MG
  • ITEM #: 11574973
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$338.00
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ITEM #: 11574973
The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
This listing is for 2 mg Glass bottle

Merck - 322337-2MG - Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 | Calbiochem | 2MG

  • Item #: 11574973
  • MFR SKU: 322337-2MG
  • Overview A 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC 50 = 11 µ M) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.
  • Catalogue Number 322337
  • Brand Family Calbiochem®
  • Synonyms Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III
  • References Zhang, Y., et al. 2009. Nat. Chem. Biol. 5, 217.
  • Form Lyophilized white solid
  • Formulation Supplied as a trifluoroacetate salt
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Hygroscopic Hygroscopic
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Peptide Sequence Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.
  • Packaged under inert gas Packaged under inert gas

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