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Merck - 324470-5MG - E-4031 | CAS 113558-89-7 | Calbiochem | 5MG

  • MFR SKU: 324470-5MG
  • ITEM #: 6310787
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ITEM #: 6310787
Inhibitor E-4031 5Mg^ 4'-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl Form Solid Cas number 113558-89-7 Purity =98% by TLC.A specific blocker of HERG channels (IC50 = 7.7 nM).
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Merck - 324470-5MG - E-4031 | CAS 113558-89-7 | Calbiochem | 5MG

  • Item #: 6310787
  • MFR SKU: 324470-5MG
  • Overview A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K + current (IK, IR) (IC 50 = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC 50 = 7.7 nM).
  • Catalogue Number 324470
  • Brand Family Calbiochem®
  • Synonyms 4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
  • References Ficker, E., et al. 2000. Am. J. Physiol. 279, H1748.
  • Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
  • Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
  • Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
  • Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
  • Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
  • West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
  • West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.
  • CAS number 113558-89-7
  • ATP Competitive N
  • Form White to off-white solid
  • Hill Formula CHNOS · 2HCl · 2HO
  • Chemical formula CHNOS · 2HCl · 2HO
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Inhibitor of the rapid type of inactivating inward-rectifying K+ current 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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