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Merck - 324693-250MG - Emetine, Dihydrochloride | CAS 316-42-7 | Calbiochem | 250MG

  • MFR SKU: 324693-250MG
  • ITEM #: 3441670
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ITEM #: 3441670
Emetine, Dihydrochloride^ 250mg white solid. 6', 7', 10, 11-Tetramethoxyemetan, 2HCl. Purity>=98% by TLC. Soluble in EtOH, H2O. CAS 316-42-7. M.W.: 553.6. Hygroscopic. Principal alkaloid of ipecac, isolated from ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes.
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Merck - 324693-250MG - Emetine, Dihydrochloride | CAS 316-42-7 | Calbiochem | 250MG

  • Item #: 3441670
  • MFR SKU: 324693-250MG
  • Overview Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha . Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC 50 ≤ 1 µ M.
  • Catalogue Number 324693
  • Brand Family Calbiochem®
  • Synonyms 6, 7, 10, 11-Tetramethoxyemetan, 2HCl
  • References Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
  • Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
  • Kokuho, T., et al. 1995. Immunobiology 193, 42.
  • Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
  • Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
  • Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
  • Landis, R.C., et al. 1991. J. Immunol. 146, 128.
  • Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
  • CAS number 316-42-7
  • ATP Competitive N
  • Form White to off-white solid
  • Hill Formula CHNO · 2HCl
  • Chemical formula CHNO · 2HCl
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Movement of ribosomes along the mRNA 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> ≤ 1 µ M as a specific inhibitor of HIF-2α protein stability and transcriptional activity
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • RTECS JY5250000
  • R Phrase R: 28-36/38
  • Very toxic if swallowed.
  • Irritating to eyes and skin.
  • S Phrase S: 28-36/37-45
  • Wear suitable protective clothing and gloves.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Ambient Temperature Only
  • Toxicity Highly Toxic
  • Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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