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Merck - 341310-5MG - FABP4 Inhibitor | CAS 300657-03-8 | Calbiochem | 5MG

  • MFR SKU: 341310-5MG
  • ITEM #: 3440923
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ITEM #: 3440923
The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.
This listing is for 5 mg Plastic ampoule

Merck - 341310-5MG - FABP4 Inhibitor | CAS 300657-03-8 | Calbiochem | 5MG

  • Item #: 3440923
  • MFR SKU: 341310-5MG
  • Overview A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (K i = < 2 nM in a competitive binding assay using 1, 8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (K i = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro , as well as improve the glucose metabolism and insulin sensitivity in mice in vivo .
  • Catalogue Number 341310
  • Brand Family Calbiochem®
  • Synonyms adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2-(5-Ethyl-3, 4-diphenyl-1H-pyrazol-1-yl)(1, 1-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
  • References Furuhashi, M., et al. 2007. Nature 447, 959.
  • Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
  • CAS number 300657-03-8
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ200
  • Purity ≥ 98% by HPLC
  • S Phrase S: 22-24/25-36-45
  • Do not breathe dust.
  • Avoid contact with skin and eyes.
  • Wear suitable protective clothing.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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