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Merck - 343781-100UG - w-Conotoxin GVIA, Conus geographus (omega-Conotoxin) | CAS 106375-28-4 | Calbiochem | 100UG

  • MFR SKU: 343781-100UG
  • ITEM #: 11575078
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ITEM #: 11575078
A neurotoxin that acts as an antagonist of voltage-activated N-type Ca 2+ channels and of neurotransmitter release at neuronal synapses.
This listing is for 100 μg Alu drum

Merck - 343781-100UG - w-Conotoxin GVIA, Conus geographus (omega-Conotoxin) | CAS 106375-28-4 | Calbiochem | 100UG

  • Item #: 11575078
  • MFR SKU: 343781-100UG
  • Overview A neurotoxin that acts as an antagonist of voltage-activated N-type Ca 2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC 50 = 21.2 nM for P2X3 and 3.84 µ M for P2X2/X3 heterooligomeric receptors).
  • Catalogue Number 343781
  • Brand Family Calbiochem®
  • Synonyms ω-CgTx GVIA
  • References Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
  • Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
  • Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
  • Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
  • Protti, D.A., et al. 1991. Brain Res. 557, 336.
  • Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
  • Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
  • Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
  • CAS number 106375-28-4
  • ATP Competitive N
  • Declaration Not available for sale outside of the United States.
  • Form Lyophilized
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible N
  • Quality Level MQ100
  • Primary Target Voltage-activated N-type Ca2+ channels 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 21.2 nM for P2X3 and 3.84 µ M for P2X2/X3 heterooligomeric receptors
  • Purity ≥ 98% by HPLC
  • Cell permeable N
  • Peptide Sequence H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹-Cys¹-Arg-Ser-Cys¹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²-Tyr-NH (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
  • R Phrase R: 26/27/28
  • Very toxic by inhalation, in contact with skin and if swallowed.
  • S Phrase S: 45-36/37/39
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Wear suitable protective clothing, gloves and eye/face protection.
  • Ship Code Ambient Temperature Only
  • Toxicity Highly Toxic
  • Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • End use certificate Y

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