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Merck - 344096-10MG - InSolution Fluvastatin, Sodium Salt | CAS 93957-55-2 | Calbiochem | 10 MG

  • MFR SKU: 344096-10MG
  • ITEM #: 6152643
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ITEM #: 6152643
A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.
This listing is for 10 mg Glass bottle

Merck - 344096-10MG - InSolution Fluvastatin, Sodium Salt | CAS 93957-55-2 | Calbiochem | 10 MG

  • Item #: 6152643
  • MFR SKU: 344096-10MG
  • Overview A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185 ), Mevastatin (Cat. No. 474700 ), and Simvastatin (Cat. No. 567020 ), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
  • Catalogue Number 344096
  • Brand Family Calbiochem®
  • Synonyms (±)-(3R, 5S, 6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3, 5-dihydroxy-6-heptenoate, sodium
  • References Yamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
  • Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
  • Ikeda, U., et al. 2000. Hypertension 36, 325.
  • Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
  • Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
  • Yuan, J., et al. 1991. Atherosclerosis 87, 147.
  • CAS number 93957-55-2
  • Form Liquid
  • Formulation A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt ( 344095 ) in HO.
  • Hill Formula CHFNNaO
  • Chemical formula CHFNNaO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target HMG-CoA reductase
  • Purity ≥ 98% by HPLC
  • Ship Code Dry Ice Only
  • Toxicity Standard Handling
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Avoid freeze/thaw Avoid freeze/thaw
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-70° C). Aliquots are stable for up to 6 months at -70° C.
  • Packaged under inert gas Packaged under inert gas

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