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Merck - 345733-500UG - Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk | Calbiochem | 500UG

  • MFR SKU: 345733-500UG
  • ITEM #: 7009942
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ITEM #: 7009942
Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk^ 500ug. Neu5Aca2, 3Galb1, 4Glcb1, 1 Ceramide, NH4. Solid. Contains mainly N-acetylneuraminic acid. GM3 is reported to inhibit certain EGF-receptor tyrosine kinase activity. Purity:>=98% TLC. MW 1198.5 (based on stearoyl-18:0).
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Merck - 345733-500UG - Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk | Calbiochem | 500UG

  • Item #: 7009942
  • MFR SKU: 345733-500UG
  • Overview Contains mainly N-acetylneuraminic acid. GM 3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM 3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC 50 = 100 - 115 µ M). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
  • M.W. 1198.5 (based on stearoyl - 18:0).
  • Catalogue Number 345733
  • Brand Family Calbiochem®
  • Synonyms Neu5Acα 2, 3Galβ 1, 4Glcβ 1, 1 Ceramide, NH
  • References Katoh, N. 1995. Life Sci. 56, 157.
  • Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
  • Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
  • Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHNO · NH
  • Chemical formula CHNO · NH
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Protein kinase C, EGF-receptor tyrosine kinase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 100 - 115 µ M inhibiting protein kinase C activity in both cytosolic and total particulate fractions
  • Purity ≥ 98% by TLC
  • Cell permeable N
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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