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Merck - 345888-10MG - Ghrelin Receptor Antagonist, JMV 2959 - Calbiochem

  • MFR SKU: 345888-10MG
  • ITEM #: 13025620
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ITEM #: 13025620
Ghrelin Receptor Antagonist, JMV 2959
, 10MG
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Merck - 345888-10MG - Ghrelin Receptor Antagonist, JMV 2959 - Calbiochem

  • Item #: 13025620
  • MFR SKU: 345888-10MG
  • Overview A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC 50 = 32 nM in a binding assay, dissociation constant K b = 19 nM). Shown to reduce hexarelin-induced food intake [hexarelin (80 µg/kg, cumulative food intake (g of food/100 g of body weight) at 6 h by acute administration (sc) of JMV 2959 (160 µg/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca 2+ mobilization.
  • Catalogue Number 345888
  • Brand Family Calbiochem®
  • Synonyms (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1, 2, 4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959, Growth hormone secretagogue receptor antagonist
  • References Moulin, A., et al. 2013. Amino Acids

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