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Merck - 349254-5MG - NS-398 | CAS 123653-11-2 | Calbiochem | 5MG

  • MFR SKU: 349254-5MG
  • ITEM #: 4148049
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ITEM #: 4148049
NS-398^ ( [N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide]). Pale yellow solid. Selective inhibitor of cyclooxygenase-2 (COX-2). In vitro, inhibits sheep placenta COX-2 (IC50 = 3.8 mM) while COX-1 activity is completely unaffected at concentrations up to 100 mM.
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Merck - 349254-5MG - NS-398 | CAS 123653-11-2 | Calbiochem | 5MG

  • Item #: 4148049
  • MFR SKU: 349254-5MG
  • Overview A cell-permeable selective inhibitor of COX-2 in vitro . Inhibits sheep placental COX-2 (IC 50 = 3.8 µ M) while COX-1 activity is unaffected at concentrations up to 100 µ M. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
  • Catalogue Number 349254
  • Brand Family Calbiochem®
  • Synonyms N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
  • References Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
  • Futaki, N., et al. 1994. Prostaglandins 47, 55.
  • Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
  • Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
  • Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
  • CAS number 123653-11-2
  • ATP Competitive N
  • Form Pale yellow solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target COX-2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 3.8 µ M against COX-2
  • Purity ≥ 98% by TLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 months at -20° C.

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