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Merck - 356790-5GM - Glyphosine - CAS 2439-99-8 - Calbiochem

  • MFR SKU: 356790-5GM
  • ITEM #: 11575112
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ITEM #: 11575112
A plant growth regulator that also enhances anti-B:9-23 TCR-dependent T cell activation by modulating murine class II MHC I-Ag7-mediated B:9-23 presentation on APCs.
This listing is for 5 gm Glass bottle

Merck - 356790-5GM - Glyphosine - CAS 2439-99-8 - Calbiochem

  • Item #: 11575112
  • MFR SKU: 356790-5GM
  • Overview A glycine-phosphonic acid compound, negatively charged at neutral pH, with immunomodulatory and anti-diabetic properties. Shown to enhance CD4 + T cell response to B-chain of insulin (amino acids 9-23) even at 10 nM levels (EC 50 = 70.6 nM). Occupies a pocket 9 of I-A g7 (the class II molecules of the diabetes-prone NOD mice) and alters TCR/peptide-MHC affinity. Stimulates IL-10 secretion in splenocyes in non-obese diabetic (NOD) mice. Daily administration of glyphosine is shown to delay the onset of diabetes in NOD mice. Acts as a competitive inhibitor of phoshoenolpyruvate carboxylase in plants.
  • Catalogue Number 356790
  • Brand Family Calbiochem®
  • Synonyms Cp41845, Polaris, N, N- bis (Phosphonomethyl)glycine, 2-( bis (Phosphonomethyl)amino)acetic acid
  • References Michels, A.W., et al. 2011. J. Immunol. 187, 5921.
  • Stadinski, B.D., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 10978.
  • Podesta, F.E., et al. 1987. Plant Cell Physiol. 28, 375.
  • CAS number 2439-99-8
  • Form White solid
  • Hill Formula CHNOP
  • Chemical formula CHNOP
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 98% by NMR
  • R Phrase R: 41
  • Risk of serious damage to eyes.
  • S Phrase S: 26
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Ship Code Ambient Temperature Only
  • Toxicity Corrosive
  • Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 year at -20° C.
  • Packaged under inert gas Packaged under inert gas

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