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Merck - 371706-10MG - GPR40 Agonist | CAS 885101-89-3 | Calbiochem | 10MG

  • MFR SKU: 371706-10MG
  • ITEM #: 6281807
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ITEM #: 6281807
The GPR40 Agonist, also referenced under CAS 885101-89-3, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 10 mg Plastic ampoule

Merck - 371706-10MG - GPR40 Agonist | CAS 885101-89-3 | Calbiochem | 10MG

  • Item #: 6281807
  • MFR SKU: 371706-10MG
  • Overview A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC 50 ~50 nM) with much reduced activity towards family members GPR120 (EC 50 ~3.5 µ M), GPR41/GPR43 (EC 50 >50 µ M), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca 2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥ 5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
  • Catalogue Number 371706
  • Brand Family Calbiochem®
  • Synonyms 3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
  • References McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
  • Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
  • CAS number 885101-89-3
  • Form Light yellow solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 98% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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