Image is an illustration, may not reflect the exact product sold.

Merck - 371715-1MG - Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem

MFR SKU: 371715-1MG

ITEM #: 4147957

- 0 out of 5 stars
- 5 Star
  0 %
- 4 Star
  0 %
- 3 Star
  0 %
- 2 Star
  0 %
- 1 Star
  0 %
0 Reviews / 0 Questions

$254.00

Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 4147957
Gliotoxin, Gladiocladium fimbriatum^ White solid. An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes.
This listing is for Each

Merck - 371715-1MG - Gliotoxin, <i>Gladiocladium fimbriatum</i> - CAS 67-99-2 - Calbiochem

Item #: 4147957

MFR SKU: 371715-1MG

Technical Specs

Overview An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes. Farnesyltransferase (FTase) inhibitor (IC 50 = 1.1 µ M). Reported to increase ryanodine Ca 2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Specifically inhibits NF-κ B activation in B and T cells at nanomolar concentrations.
Catalogue Number 371715
Brand Family Calbiochem®
Synonyms 2, 3, 5a, 6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a, 10a-epidithio-pyrazinol[1, 2α]indole-1, 4-dione
References Green, D., et al. 2000. J. Membr. Biol. 175, 223.
Sutton, P., et al. 1995. Transplantation 60, 900.
Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195.
Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403.
Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802.
Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067.
Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.
CAS number 67-99-2
ATP Competitive N
Form White solid
Hill Formula CHNOS
Chemical formula CHNOS
Reversible N
Structure formula Image

Quality Level MQ100
Primary Target FTase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"

br> Primary Target IC<sub> 50</sub> 1.1 µ M against Farnesyltransferase (FTase)
Purity ≥ 98% by TLC
Cell permeable N
RTECS KB4725000
R Phrase R: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2° C to +8° C
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 1 month at -20° C.

Questions & Answers

Add Question

0 Customer Ratings & Reviews

Review this product

Tell us about your personal experience

Write a review

5 Star		0 %
4 Star		0 %
3 Star		0 %
2 Star		0 %
1 Star		0 %