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Merck - 373226-5MG - Hdm2 E3 Ligase Inhibitor II, HLI373 - CAS 502137-98-6 - Calbiochem

  • MFR SKU: 373226-5MG
  • ITEM #: 11575157
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ITEM #: 11575157
The Hdm2 E3 Ligase Inhibitor II, HLI373, also referenced under CAS 502137-98-6, controls the biological activity of Hdm2 E3 Ligase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
This listing is for 5 mg Glass bottle

Merck - 373226-5MG - Hdm2 E3 Ligase Inhibitor II, HLI373 - CAS 502137-98-6 - Calbiochem

  • Item #: 11575157
  • MFR SKU: 373226-5MG
  • Overview A cell-permeable pyrimidoquinoline-dione compound that upregulates cellular p53 and E3 ubiquitin ligase HDM2/MDM2 protein levels (optimal conc. = 5 µ M in RPE cells) by directly inhibiting MDM2 E3 ubiquitin ligase activity. Shown to induce apoptotic cell death in E1A-transformed, but not non-transformed, RPE cells and be more active toward wild-type p53-expressing than mutant p53-expressing cancer cells (≥ 67% vs. ≤ 37% death induction, respectively; 25 µ M 30 h treatment).
  • Catalogue Number 373226
  • Brand Family Calbiochem®
  • Synonyms MDM2 Inhibitor VI, MDM2 E3 Ligase Inhibitor II, 5-(3-Dimethylaminopropylamino)-3, 10-dimethyl-10H-pyrimido[4, 5-b]quinoline-2, 4-dione, 2HCl
  • References Kitagaki, J., et al. 2008. Mol. Cancer Ther. 7, 2445.
  • Yang, Y., et al. 2005. Cancer Cell 7, 547.
  • CAS number 502137-98-6
  • Form Cream solid
  • Hill Formula CHNO • 2HCl
  • Chemical formula CHNO • 2HCl
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 98% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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