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Merck - 373273-10MG - Hh Signaling Antagonist XIV, SANT-2 | CAS 329196-48-7 | Calbiochem | 10 MG

  • MFR SKU: 373273-10MG
  • ITEM #: 11575160
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ITEM #: 11575160
The Hh Signaling Antagonist XIV, SANT-2, also referenced under CAS 329196-48-7, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
This listing is for 10 mg

Merck - 373273-10MG - Hh Signaling Antagonist XIV, SANT-2 | CAS 329196-48-7 | Calbiochem | 10 MG

  • Item #: 11575160
  • MFR SKU: 373273-10MG
  • Overview A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303 ), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803 ) by SANT-1 and SANT-2 (K i = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661 ) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µ M).
  • Catalogue Number 373273
  • Brand Family Calbiochem®
  • Synonyms N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3, 4, 5-tris(ethyloxy)benzamide, Smo Antagonist V
  • References Rominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
  • Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
  • Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
  • Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
  • CAS number 329196-48-7
  • Form White powder
  • Hill Formula CHClNO
  • Chemical formula CHClNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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