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Merck - 374000-500UG - Helenalin, A. chamissonis ssp. foliosa

  • MFR SKU: 374000-500UG
  • ITEM #: 13026922
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ITEM #: 13026922
Helenalin, Arnica chamissonis
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Merck - 374000-500UG - Helenalin, A. chamissonis <i>ssp. foliosa</i>

  • Item #: 13026922
  • MFR SKU: 374000-500UG
  • Overview A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κ B-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κ B activation/nuclear translocation or Iκ B dissociation/degradation. An excellent research tool for studying NF-κ B-mediated biological processes both in cultures in vitro and in animals in vivo .
  • Catalogue Number 374000
  • Brand Family Calbiochem®
  • References Boulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
  • Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
  • Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
  • Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
  • Lyss, G., et al. 1997. Biol. Chem. 378, 951.
  • CAS number 6754-13-8
  • Form White to off-white solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • RTECS BD9630000
  • Ship Code Dry Ice Only
  • Toxicity Toxic
  • Storage -20° C
  • Protect from Light Protect from light
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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