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Merck - 376650-5MG - D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

  • MFR SKU: 376650-5MG
  • ITEM #: 3441379
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ITEM #: 3441379
D-erythro-Sphingosine, N-Hexanoyl-^ (C6 Ceramide). Waxy solid. Biologically active, cell-permeable, nonphysiological ceramide analog. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM.
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Merck - 376650-5MG - D-<i>erythro</i>-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

  • Item #: 3441379
  • MFR SKU: 376650-5MG
  • Overview Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G 0 /G 1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
  • Catalogue Number 376650
  • Brand Family Calbiochem®
  • Synonyms C Ceramide
  • References Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
  • Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
  • Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
  • Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
  • Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
  • CAS number 124753-97-5
  • ATP Competitive N
  • Form White waxy solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target MAP kinase, protein phosphatase 2A (PP2A) 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
  • Purity ≥ 95% by TLC
  • Cell permeable Y
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 months at -20° C.

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