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Merck - 382192-2MG - HMTase Inhibitor IV, UNC0638 | Calbiochem | 2 MG

  • MFR SKU: 382192-2MG
  • ITEM #: 11575192
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$210.50
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ITEM #: 11575192
The HMTase Inhibitor IV, UNC0638 controls the biological activity of HMTase. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 2 mg Glass bottle

Merck - 382192-2MG - HMTase Inhibitor IV, UNC0638 | Calbiochem | 2 MG

  • Item #: 11575192
  • MFR SKU: 382192-2MG
  • Overview A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC 50 = ≤ 15 and 19 nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over DNMT1 and minimally blocks the activities of JMJD2E (IC 50 = 4.66 µ M) and SETD7, SETD8, PRMT3 and SUV39H2 (IC 50 > 10 µ M). Shown to lower H3K9Me2 levels in MDA-MB231 cells (IC 50 = 81 nM; EC 50 = 11.2 µ M for cell toxicity) and 6-fold more potent than the HMTase Inhibitor, BIX-01294, (Cat. No. 382190 ). Also, affects the activities of adrenergic α 1A , adrenergic α 1B and muscarinic M2 by 90%, 69% and 64% and a panel of 26-receptors and ion-channels by ≤ 30% at 1 µ M.
  • This probe is supplied in conjunction with the Structural Genomics Consortium (SGC). For further characterization details, please visit the UNC0638 probe summary on the SGC website.
  • Catalogue Number 382192
  • Brand Family Calbiochem®
  • Synonyms 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine, DNA Methyltransferase Inhibitor III, DNA MTase Inhibitor III, EHMT1/GLP Inhibitor II, EHMT2/G9a Inhibitor IV
  • References Vedadi, M., et al. 2011. Nat. Chem. Biol. 7, 566.
  • Liu, F., et al. 2011. J. Med. Chem. 54, 6139.
  • Form Off-white powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 99% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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