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Merck - 385581-10MG - 11beta-HSD1 Inhibitor, 10j | CAS 1009373-58-3 | Calbiochem | 10 MG

  • MFR SKU: 385581-10MG
  • ITEM #: 11575196
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ITEM #: 11575196
The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
This listing is for 10 mg

Merck - 385581-10MG - 11beta-HSD1 Inhibitor, 10j | CAS 1009373-58-3 | Calbiochem | 10 MG

  • Item #: 11575196
  • MFR SKU: 385581-10MG
  • Overview A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC 50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
  • Catalogue Number 385581
  • Brand Family Calbiochem®
  • References Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
  • CAS number 1009373-58-3
  • Form White solid
  • Hill Formula CHBrNO
  • Chemical formula CHBrNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.

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