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Merck - 399275-5MG - Nw-Hydroxy-nor-L-arginine, Diacetate Salt | CAS 189302-40-7 | Calbiochem | 5MG

  • MFR SKU: 399275-5MG
  • ITEM #: 6281016
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ITEM #: 6281016
N omega Hydroxy-nor-L-arginine, Diacetate Salt^ 5mg. L-2-Amino-(4-(2'-hydroxyguanidino)butyric Acid, 2CH3CO2H. nor-NOHA, 2CH3CO2H. Off-white solid. Hygroscopic. High affinity inhibitor of arginase. Inhibits arginase from rat liver and mouse macrophages. Purity:>=97% by TLC. CAS 189302-40-7.
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Merck - 399275-5MG - Nw-Hydroxy-nor-L-arginine, Diacetate Salt | CAS 189302-40-7 | Calbiochem | 5MG

  • Item #: 6281016
  • MFR SKU: 399275-5MG
  • Overview A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC 50 = 2 µ M) and mouse macrophages (IC 50 = 50 µ M). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
  • Catalogue Number 399275
  • Brand Family Calbiochem®
  • Synonyms nor-NOHA, 2CHCOH, L-2-Amino-(4-(2-hydroxyguanidino)butyric Acid, 2CHCOH
  • References Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
  • Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
  • Moali, C., et al. 2000. Biochemistry 39, 8208.
  • Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
  • Moali, C., et al. 1998. Biochemistry 37, 10453.
  • Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
  • CAS number 189302-40-7
  • Form Off-white solid
  • Hill Formula CHNO · 2CHCOH
  • Chemical formula CHNO · 2CHCOH
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Application Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µ M for rat liver and 50 µ M for mouse macrophages).
  • Primary Target arginase from rat liver 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 2 µ M
  • Secondary target mouse macrophages (IC = 50 µ M)
  • Purity ≥ 97% by TLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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