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Merck - 400091-50MG - HIF-Hydroxylase Inhibitor, DMOG | CAS 89464-63-1 | Calbiochem | 50MG

  • MFR SKU: 400091-50MG
  • ITEM #: 11575222
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ITEM #: 11575222
HIF-Hydroxylase Inhibitor, DMOG, CAS 89464-63-1, is a cell-permeable 2-oxoglutarate (2-OG) analog that acts as a competitive inhibitor against all 2-OG-dependent dioxygenases.
This listing is for 50 mg Glass bottle

Merck - 400091-50MG - HIF-Hydroxylase Inhibitor, DMOG | CAS 89464-63-1 | Calbiochem | 50MG

  • Item #: 11575222
  • MFR SKU: 400091-50MG
  • Overview A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-α transcription activity (effective conc. = 1 mM in cultures) by inhibiting HIF-PH- (HIF-α-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro 564 and Pro 530 in HIF-1α and HIF-2α, respectively) and aspartyl/asparanginyl β-hydroxylase-catalyzed CAD Asp hydroxylation (Asn 803 and Asn 851 in HIF-1α and HIF-2α, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-α degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association. DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1α and FLK (by 100% and 40%, respectively, in 11 days; 8 mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo .
  • Catalogue Number 400091
  • Brand Family Calbiochem®
  • Synonyms N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor
  • References Pollard, P.J., et al. 2008. Biochem. J. 416, 387.
  • Chen, H., et al. 2006. Cancer Res. 66, 9009.
  • Milkiewicz, M., et al. 2004. J. Physiol. 560, 21.
  • Lando, D., et al. 2002. Science 295, 858.
  • Jaakkola, P., et al. 2001. Science 292, 468.
  • CAS number 89464-63-1
  • Form Pink-white to peach-white
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Hygroscopic Hygroscopic
  • Structure formula Image
  • Quality Level MQ100
  • Application HIF-Hydroxylase Inhibitor, DMOG, CAS 89464-63-1, is a cell-permeable 2-oxoglutarate (2-OG) analog that acts as a competitive inhibitor against all 2-OG-dependent dioxygenases.
  • Purity ≥ 98% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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