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Merck - 401003-1GM - ()-Ibuprofen - CAS 15687-27-1 - Calbiochem

  • MFR SKU: 401003-1GM
  • ITEM #: 3450438
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ITEM #: 3450438
(+/-) Ibuprofen^ 1gm. [(+/-)-2-(4-Isobutylphenyl)-propionic Acid. White solid. Nonsteroidal anti-inflammatory drug (NSAID) acts as reversible & competitive cyclooxygenase 1 (COX-1)inhibitor. Inhibits COX-2 at higher concentrations. Purity>=99% titration. RTECS MU6640000, CAS 15687-27-1. MW 206.3.
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Merck - 401003-1GM - ()-Ibuprofen - CAS 15687-27-1 - Calbiochem

  • Item #: 3450438
  • MFR SKU: 401003-1GM
Technical Specs
  • Overview A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC 50 = 4.85 µ M). Inhibits COX-2 at higher concentrations (IC 50 = 223 µ M). Blocks aspirin inactivation of COX-1 (EC 50 antagonism of 200 µ M aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β 40 and 42 ) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µ M-500 µ M).
  • Catalogue Number 401003
  • Brand Family Calbiochem®
  • Synonyms [(±)-2-(4-Isobutylphenyl)-propionic Acid
  • References Asanuma, M., et al. 2001. J. Neurochem. 76, 1895.
  • Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
  • Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
  • Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
  • Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
  • Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
  • Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
  • Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
  • Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
  • Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
  • Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.
  • CAS number 15687-27-1
  • ATP Competitive Y
  • Form White solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target COX-1 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 4.85 µ M against COX-1
  • Purity ≥ 98% by titration
  • Cell permeable N
  • RTECS MU6640000
  • R Phrase R: 22
  • Harmful if swallowed.
  • S Phrase S: 36
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage +15° C to +30° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
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