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Merck - 401480-1MG - IKK Inhibitor III, BMS-345541 | CAS 445430-58-0 | Calbiochem | 1 MG

  • MFR SKU: 401480-1MG
  • ITEM #: 6281302
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ITEM #: 6281302
IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC = ~ 300 nM).
This listing is for 1 mg Plastic ampoule

Merck - 401480-1MG - IKK Inhibitor III, BMS-345541 | CAS 445430-58-0 | Calbiochem | 1 MG

  • Item #: 6281302
  • MFR SKU: 401480-1MG
  • Overview A cell-permeable quinoxaline compound that displays anti-inflammatory properties. Acts as a potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC 50 = ~ 300 nM). Exhibits ~10-fold greater selectivity over IKK-1 (IC 50 = ~ 4 µ M) and no activity towards IKKε and a panel of more than 15 unrelated protein kinases even at concentrations as high as 100 µ M. Inhibits cellular Iκ Bα phosphorylation (IC 50 = 4 µ M in THP-1 cells) and LPS-induced cytokine production both in vitro (IC 50 = 1-5 µ M in THP-1 cells) and in vivo (IC 50 = 10 mg/kg in mice). Effectively blocks inflammation and joint destruction in a murine arthritis model.
  • Catalogue Number 401480
  • Brand Family Calbiochem®
  • Synonyms 4-(2-Aminoethyl)amino-1, 8-dimethylimidazo[1, 2-a]quinoxaline
  • References Townsend, R.M., et al. 2004. Transplantation 77, 1090.
  • MacMaster, J.F., et al. 2003. Inflamm. Res. 52, 508.
  • McIntyre, K.W., et al. 2003. Arthritis Rheum. 48, 2652.
  • Burke, J. R., et al. 2003. J. Biol. Chem. 278, 1450.
  • CAS number 445430-58-0
  • ATP Competitive N
  • Form Off-white solid
  • Formulation Supplied as bis-TFA salt.
  • Hill Formula CHN• 2CFCOH
  • Chemical formula CHN• 2CFCOH
  • Hygroscopic Hygroscopic
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target IKK-2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> ~300 nM against IKK-2; 4 µ M against cellular Iκ Bα phosphorylation in THP-1 cells; 1-5 µ M LPS-induced cytokine production in THP-1 cells
  • Purity ≥ 96% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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