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Merck - 405268-10GM - Indomethacin | CAS 53-86-1 | Calbiochem | 10GM

  • MFR SKU: 405268-10GM
  • ITEM #: 3441711
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ITEM #: 3441711
Indomethacin^ ( [1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid]). Off-white solid. A non-steroidal anti-inflammatory, antipyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 mM).
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Merck - 405268-10GM - Indomethacin | CAS 53-86-1 | Calbiochem | 10GM

  • Item #: 3441711
  • MFR SKU: 405268-10GM
  • Overview A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC 50 = 740 nM for COX-1; IC 50 = 970 nM for COX-2). Inhibits phospholipase A 2 (IC 50 = 145 µ M). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
  • Catalogue Number 405268
  • Brand Family Calbiochem®
  • Synonyms 1-( p -Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
  • References Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
  • Weggen, S., et al. 2001. Nature 414, 212.
  • Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
  • Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
  • Futaki, N., et al. 1994. Prostaglandins 47, 55.
  • Futaki, N., et al. 1994. Prostaglandins 47, 55.
  • Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
  • Oliw, E. 1980. Prostaglandins 19, 271.
  • CAS number 53-86-1
  • ATP Competitive N
  • Form White to off-white powder
  • Hill Formula CHClNO
  • Chemical formula CHClNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target COX-1 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 740 nM
  • Purity ≥ 98% by assay
  • Cell permeable Y
  • RTECS NL3500000
  • R Phrase R: 28-42/43-63
  • Very toxic if swallowed.
  • May cause sensitization by inhalation and skin contact.
  • Possible risk of harm to the unborn child.
  • S Phrase S: 36/37/39-45
  • Wear suitable protective clothing, gloves and eye/face protection.
  • In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
  • Ship Code Ambient Temperature Only
  • Toxicity Highly Toxic & Carcinogenic / Teratogenic
  • Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.

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