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Merck - 406170-5MG - IP6K Inhibitor | CAS 519178-28-0 | Calbiochem | 5MG

  • MFR SKU: 406170-5MG
  • ITEM #: 6281631
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ITEM #: 6281631
The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K.
This listing is for 5 mg Plastic ampoule

Merck - 406170-5MG - IP6K Inhibitor | CAS 519178-28-0 | Calbiochem | 5MG

  • Item #: 6281631
  • MFR SKU: 406170-5MG
Technical Specs
  • Overview A cell-permeable 2, 6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1, 4, 5)P 3 (Cat. Nos. 407123 & 407137 ) to Ins(1, 3, 4, 5)P 4 (Cat. No. 407126 ) by IP3K (IC 50 = 18 µ M; [ATP] = 10 μ M), acts in fact as a much more effective inhibitor against the IP6K1/2/3-catalyzed conversion of InsP 6 (Cat. No. 407125 ) to 5-[PP]- InsP 6 or InsP 7 (IC 50 = 0.47 μ M against IP6K1; [ATP] = 1 mM) due to a much higher affinity of ATP toward IP3K than IP6K ( K m of ATP for the respective enzymes = 0.01 vs 1000 μ M). Shown to potently inhibit cellular InsP 7 level (IC 50 = 0.55 μ M in HeLa cultures), while being less potent in increasing the cellular InsP 3 accumulation (>10 µ M in HeLa cultures). TNP is also effective against S. cerevisiae IP6K, Kcs1, but not Vip/PPIP5Ks, enzymes that catalyze the pyrophosphorylation at the 1/3 position of InsP 6 and InsP 7 , in either human or yeast species or two other IP3 metabolizing enzymes, PLC and IP3 5-ppase.
  • Catalogue Number 406170
  • Brand Family Calbiochem®
  • Synonyms N²-( m -Trifluorobenzyl), N-( p -nitrobenzyl)purine, Inositol-1, 4, 5-trisphosphate 3-Kinase Inhibitor, IP3K Inhibitor, Kcs1 Inhibitor, TNP
  • References Padmanabhan, U., et al. 2009. J. Biol. Chem. 284, 10571. Chang, Y.T., et al. 2002. ChemBioChem 3, 897.
  • CAS number 519178-28-0
  • ATP Competitive Y
  • Form Yellow solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target IP 3-K 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.47 µ M against IP6K1; [ATP] = 1 mM; 18 µ M against the conversion of Ins(1, 4, 5)P3 to Ins(1, 3, 4, 5)P4 by IP3K; [ATP] = 10 µ M
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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