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Merck - 412400-10MG - IQ-1 | CAS 331001-62-8 | Calbiochem | 10MG

  • MFR SKU: 412400-10MG
  • ITEM #: 11435195
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ITEM #: 11435195
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
This listing is for 10 mg Plastic ampoule

Merck - 412400-10MG - IQ-1 | CAS 331001-62-8 | Calbiochem | 10MG

  • Item #: 11435195
  • MFR SKU: 412400-10MG
  • Overview A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
  • Catalogue Number 412400
  • Brand Family Calbiochem®
  • Synonyms 2-(4-Acetylphenylazo)-2-(3, 3-dimethyl-3, 4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III
  • References Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 5668.
  • CAS number 331001-62-8
  • Form Orange solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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