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Merck - 420107-50UG - Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

  • MFR SKU: 420107-50UG
  • ITEM #: 3450372
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ITEM #: 3450372
Jasplakinolide, Jaspis johnstoni^ 50ug.Yellow solid. Cell-permeable F-actin probe. Cyclodepsipeptide with antifungal and antitumor properties. Inducer of actin polymerization & stabilization in vitro. Purity>=85% by HPLC. CAS 102396-24-7. Protect from light.
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Merck - 420107-50UG - Jasplakinolide, <i>Jaspis johnstoni</i> - CAS 102396-24-7 - Calbiochem

  • Item #: 3450372
  • MFR SKU: 420107-50UG
  • Overview A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro . Prevents activation of store-mediated Ca 2+ entry into cells. It competes with Phalloidin (Cat. No. 516640 ) for actin binding (K d = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127 ) in DMSO is also available.
  • Catalogue Number 420107
  • Brand Family Calbiochem®
  • References Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
  • Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
  • Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
  • Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
  • Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
  • CAS number 102396-24-7
  • ATP Competitive N
  • Form Off-white solid
  • Hill Formula CHBrNO
  • Chemical formula CHBrNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
  • Primary Target Inducer of actin polymerization and stabilization in vitro 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> Kd = 15 nM for actin binding
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • R Phrase R: 20/21/22
  • Harmful by inhalation, in contact with skin and if swallowed.
  • S Phrase S: 36
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Harmful
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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