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Merck - 420135-5MG - JNK Inhibitor VIII | CAS 894804-07-0 | Calbiochem | 5MG

  • MFR SKU: 420135-5MG
  • ITEM #: 6281695
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ITEM #: 6281695
JNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).
This listing is for 5 mg Plastic ampoule

Merck - 420135-5MG - JNK Inhibitor VIII | CAS 894804-07-0 | Calbiochem | 5MG

  • Item #: 6281695
  • MFR SKU: 420135-5MG
  • Overview A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (K i = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC 50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
  • Catalogue Number 420135
  • Brand Family Calbiochem®
  • Synonyms N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2, 5-dimethoxyphenyl)acetamide
  • References Vivanco, I., et al. 2007. Cancer Cell 11, 555.
  • Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
  • CAS number 894804-07-0
  • ATP Competitive Y
  • Form Brown solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Application JNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).
  • Primary Target JNK i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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