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Merck - 420220-10MG - iPSC Induction Enhancer, Thiazovivin | Calbiochem | 10MG

  • MFR SKU: 420220-10MG
  • ITEM #: 11575272
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ITEM #: 11575272
iPSC Induction Enhancer, Thiazovivin, CAS 1226056-71-8, is a cell-permeable ROCK inhibitor that prevents trypsinization-induced apoptosis in hESC cultures.
This listing is for 10 mg Plastic ampoule

Merck - 420220-10MG - iPSC Induction Enhancer, Thiazovivin | Calbiochem | 10MG

  • Item #: 11575272
  • MFR SKU: 420220-10MG
  • Overview A cell-permeable aminothiazolo-carboxamide compound that is ~5-fold more potent than Y-27632 (Cat. Nos. 688000 & 688001 ) as a ROCK inhibitor (71% inhibition at 2 µ M). Effectively prevents trypsinization-induced apoptosis in hESC cultures by stabilizing newly synthesized cell surface E-cadherin and cell-cell adhesion. Unlike, Ptn (Cat. No. 544049 ), Tzv protects dissociated hESCs even in the absence of ECM. Greatly augments SB431542 (Cat. No. 616461 ) and PD0325901 (Cat. No. 444966 ) in improving iPSCs generation efficiency from 4-TF- ( Oct4 4, Klf4 , Sox2 , and c- Myc ) transfected fibroblast cultures.
  • Catalogue Number 420220
  • Brand Family Calbiochem®
  • Synonyms N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, Induced Pluripotent Stem Cells Induction Enhancer, Rho Kinase Inhibitor XII
  • References Xu, Y., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 8129
  • Lin, T., et al. 2009. Nat. Methods 6, 805.
  • Form Tan powder
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Structure formula Image
  • Quality Level MQ100
  • Application iPSC Induction Enhancer, Thiazovivin, CAS 1226056-71-8, is a cell-permeable ROCK inhibitor that prevents trypsinization-induced apoptosis in hESC cultures.
  • Purity ≥ 98% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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