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Merck - 420345-25MG - Kaempferol | CAS 520-18-3 | Calbiochem | 25MG

  • MFR SKU: 420345-25MG
  • ITEM #: 6281035
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ITEM #: 6281035
A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells.
This listing is for 25 mg Glass bottle

Merck - 420345-25MG - Kaempferol | CAS 520-18-3 | Calbiochem | 25MG

  • Item #: 6281035
  • MFR SKU: 420345-25MG
  • Overview A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ 25-35 -induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC 50 = 180 µ M), and of transcriptional activation of COX-2 (IC 50
  • Primary Target IC<sub> 50</sub> 180 µ M against COX-1 activity
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • RTECS LK9275200
  • R Phrase R: 36/37/38-40
  • Irritating to eyes, respiratory system and skin.
  • Limited evidence of a carcinogenic effect.
  • S Phrase S: 22-26-36
  • Do not breathe dust.
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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