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Merck - 420350-10MG - ICMT Inhibitor | Calbiochem | 10MG

  • MFR SKU: 420350-10MG
  • ITEM #: 11575278
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$317.00
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ITEM #: 11575278
The ICMT Inhibitor controls the biological activity of ICMT. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 10 mg Glass bottle

Merck - 420350-10MG - ICMT Inhibitor | Calbiochem | 10MG

  • Item #: 11575278
  • MFR SKU: 420350-10MG
  • Overview A cell-permeable indole acetamide that acts as a substrate-competitive and AdoMet-noncompetitive Icmt (isoprenylcysteine carboxyl methyltransferase) inhibitor ( K i = 0.02 µ M; IC 50 = 0.29 µ M; Substrate = S-farnesyl-L-cysteine), exhibiting no activity against FTase, gernaylgeranyltransferase type I, CaaX protease Rce1, AdoMet-dependent DNA methyltransferase, SssI DNA methyltransferase, or PCMT1 protein methyltransferase. Cysmethynil (25 µ M) induces G1 cell cycle-arrest and autophagy-mediated, but not apoptotic, cell death in prostate cancer PC3 cells with concomitant PI 3-K/Akt and mTOR signaling blockage, consistent with inhibition of Icmt-mediated activation of Ras and Rheb GTPases. Murine PC3 xenograft studies reveal limited in vivo efficacy.
  • Catalogue Number 420350
  • Brand Family Calbiochem®
  • Synonyms 2-(5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl)acetamide, 2-(1-Octyl-5-m-tolyl-1H-indol-3-yl) acetamide, Cysmethynil, Cysmethynil, Isoprenylcysteine Carboxyl Methyltransferase Inhibitor
  • References Go, M.L., et al. 2010. J. Med. Chem. 53, 6838; Wang, M., et al. 2008. J. Biol. Chem. 283, 18678; Baron, R.A., et al. 2007. Biochemistry 46, 554; Winter-Vann, A.M., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 4336.
  • Form Pale yellow semi-solid
  • Hill Formula CHN0
  • Chemical formula CHN0
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C).
  • Packaged under inert gas Packaged under inert gas

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