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Merck - 420361-10MG - KMO Inhibitor II, JM6 | Calbiochem | 10 MG

  • MFR SKU: 420361-10MG
  • ITEM #: 13025323
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$296.00
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ITEM #: 13025323
The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
This listing is for 10 mg Glass bottle

Merck - 420361-10MG - KMO Inhibitor II, JM6 | Calbiochem | 10 MG

  • Item #: 13025323
  • MFR SKU: 420361-10MG
  • Overview An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360 ) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC 50 = 4 µ M) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.
  • Catalogue Number 420361
  • Brand Family Calbiochem®
  • Synonyms Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3, 4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
  • References Campesan, S., et al. 2011. Chem. Biol. 21, 961.
  • Zwilling, D., et al. 2011. Cell 145, 863.
  • Form Yellow powder
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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