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Merck - 435801-25MG - Licofelone, Potassium Salt, Monohydrate - CAS 156897-06-2 - Calbiochem

  • MFR SKU: 435801-25MG
  • ITEM #: 17951105
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ITEM #: 17951105
This listing is for 25 mg Glass bottle

Merck - 435801-25MG - Licofelone, Potassium Salt, Monohydrate - CAS 156897-06-2 - Calbiochem

  • Item #: 17951105
  • MFR SKU: 435801-25MG
  • Overview A cell-permeable, orally active arylpyrrolizine carboxylate that is structurally and pharmacologically similar to, but less potent than, MK-886 (Cat. No. 475889 ). Effectively suppresses cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2 (IC 50 = 0.8, 6, and >30 µ M, respectively), and inhibits cellular 5-LO (5-Lypoxygenase; Cat. No. 437996 ) pathway activation (IC 50 = 0.18 to 3.6 µ M against ionophore-stimulated LB4 production from bovine and human PMNL, respectively) by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity. Unlike NSAIDs that target only COX pathway, Licofelone does not cause gastrointestinal damages when applied in vivo .
  • Catalogue Number 435801
  • Brand Family Calbiochem®
  • Synonyms 2, 2-Dimethyl-6-(4-chlorophenyl)-7-phenyl, 2, 3-dihydro-1H-pyrrolizine-5-yl)-acetic acid, ML3000, ML-3000, COX-1 Inhibitor V, FLAP Inhibitor II, mPGES-1 Inhibitor II
  • References Laufer, S. A., et al. 1994. Arzneimittelforschung. 44, 629.
  • Laufer, S., et al. 1994. Arzneimittelforschung. 45, 27.
  • Wallace, J. L., et al. 1994. Eur J Pharmacol. 271, 525.
  • Alvaro-Garcia, J. M., et al. 2004. Rheumatology. 43 Supple1, i21.
  • Koeberle, A., et al. 2008. J Pharmacol Exp Ther. 326, 975.
  • Fischer, L., et al. 2007. Br J Pharmacol. 152, 471.
  • Laufer, S. A., et al. 1994. J Med Chem. 37, 1894.
  • Vidal, C., et al. 2007. J Pharmacol Exp Ther. 320, 108.
  • Liedtke, A. J., et al. 2009. J Med Chem. 52, 4968.
  • Bias, P., et al. 2004. Am J Gastroenterol. 99, 611.
  • CAS number 156897-06-2
  • Form White powder
  • Hill Formula CHClKNO• HO
  • Chemical formula CHClKNO• HO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target 5-LOX 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.21 µ
  • Secondary target COX
  • Purity ≥ 99% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Unstable in solution. Reconstitute just prior to use.
  • Packaged under inert gas Packaged under inert gas

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