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Merck - 438187-5MG - InSolution Lovastatin, Sodium Salt | Calbiochem | 5 MG

  • MFR SKU: 438187-5MG
  • ITEM #: 6152645
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ITEM #: 6152645
Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.
This listing is for 5 mg Glass bottle

Merck - 438187-5MG - InSolution Lovastatin, Sodium Salt | Calbiochem | 5 MG

  • Item #: 6152645
  • MFR SKU: 438187-5MG
  • Overview Carboxylate form of Lovastatin (Cat. No. 438185 ) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21 ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21 ras , which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
  • Catalogue Number 438187
  • Brand Family Calbiochem®
  • References Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
  • Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
  • McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
  • Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
  • Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
  • Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
  • Form Liquid
  • Formulation A 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186 ) in HO.
  • Hill Formula CHO • Na
  • Chemical formula CHO • Na
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target HMG-CoA reductase
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • S Phrase S: 24/25
  • Avoid contact with skin and eyes.
  • Ship Code Dry Ice Only
  • Toxicity Harmful
  • Storage ≤ -70° C
  • Protect from Light Protect from light
  • Avoid freeze/thaw Avoid freeze/thaw
  • Do not freeze Ok to freeze
  • Special Instructions Following initial thaw, aliquot and freeze (-70° C). Aliquots are stable for up to 6 months at -70° C.
  • Packaged under inert gas Packaged under inert gas

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