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Merck - 438210-10MG - LSF Inhibitor, FQI1 | Calbiochem | 10 MG

  • MFR SKU: 438210-10MG
  • ITEM #: 11575311
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$234.50
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ITEM #: 11575311
The LSF Inhibitor, FQI1 controls the biological activity of LSF.
This listing is for 10 mg Glass bottle

Merck - 438210-10MG - LSF Inhibitor, FQI1 | Calbiochem | 10 MG

  • Item #: 11575311
  • MFR SKU: 438210-10MG
  • Overview A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC 50 = 2.1 µ M in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI 50 = 3.8, 0.79, and 6.3 µ M in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
  • Catalogue Number 438210
  • Brand Family Calbiochem®
  • Synonyms (±)(8-(2-Ethoxyphenyl)-7, 8-dihydro-[1, 3]dioxolo[4, 5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
  • Application Data
  • References Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
  • Form White powder
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Quality Level MQ100
  • Purity >92% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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