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Merck - 445874-5MG - mGluR5 Antagonist, MTEP | CAS 329205-68-7 | Calbiochem | 5 MG

  • MFR SKU: 445874-5MG
  • ITEM #: 6280251
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ITEM #: 6280251
The mGluR5 Antagonist, MTEP, also referenced under CAS 329205-68-7, controls the biological activity of mGluR5. This small molecule/inhibitor is primarily used for Neuroscience applications.
This listing is for 5 mg Plastic ampoule

Merck - 445874-5MG - mGluR5 Antagonist, MTEP | CAS 329205-68-7 | Calbiochem | 5 MG

  • Item #: 6280251
  • MFR SKU: 445874-5MG
  • Overview A brain-permeable (thiazole-pyridine)alkyne compound that acts as a potent, selective and non-competitive mGluR5 (metabotropic glutamate receptor subtype-5) antagonist (IC 50 = 5 nM in Ca 2+ -flux assay; K i = 16 nM) with in vivo anxiolytic activity in a rodent model (ED 50 = 1 mg/kg, ip and 7 mg/kg, po). Devoid of any side effects seen with MPEP and benzodiazepines. Reported to weakly affect the activities of other enzymes and receptors tested (IC 50 = 30 µ M for MAO-A, > 100 µ M for mGlu1R, 2R & 7R, and > 300 µ M for NR2BR).
  • Catalogue Number 445874
  • Brand Family Calbiochem®
  • Synonyms 3-((2-Methyl-1, 3-thiazol-4-yl)ethynyl)pyridine
  • References Bradbury, M.J., et al. 2005. J. Pharmacol. Exp. Ther. 313, 395.
  • Busse, C.S., et al. 2004. Neuropsychopharmacology 29, 1971.
  • Roppe, J.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3993.
  • Klodzinska, A., et al. 2004. Neuropharmacology 47, 342.
  • Cosford, N.D.P., et al. 2003. J. Med. Chem. 46, 204.
  • Brodkin, J., et al. 2002. Eur. J. Neurosci. 16, 2241.
  • CAS number 329205-68-7
  • ATP Competitive N
  • Form White to yellow solid
  • Hill Formula CHNS
  • Chemical formula CHNS
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target mGluR5 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 5 nM in Ca2+-flux assay i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5)
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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