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Merck - 454586-10MG - NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105) | Calbiochem | 10 mg

  • MFR SKU: 454586-10MG
  • ITEM #: 11575350
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ITEM #: 11575350
The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.
This listing is for 10 mg Glass bottle

Merck - 454586-10MG - NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105) | Calbiochem | 10 mg

  • Item #: 11575350
  • MFR SKU: 454586-10MG
  • Overview A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC 50 = 5.4 µ M) and GluN1/GluN2D (2.2 µ M) over GluN1/GluN2B (206 µ M) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC 50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
  • Catalogue Number 454586
  • Brand Family Calbiochem®
  • Synonyms DQP-1105, NMDA Antagonist IV
  • References Acker, T., et al. 2011. Mol. Pharmacol. 80, 782.
  • Form Yellow-white solid
  • Hill Formula CHBrNO
  • Chemical formula CHBrNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Regulatory Review
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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