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Merck - 475741-10MG - MAGL Inhibitor III, JZL184 | CAS 1101854-58-3 | Calbiochem | 10 MG

  • MFR SKU: 475741-10MG
  • ITEM #: 11575402
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ITEM #: 11575402
The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL.
This listing is for 10 mg Glass bottle

Merck - 475741-10MG - MAGL Inhibitor III, JZL184 | CAS 1101854-58-3 | Calbiochem | 10 MG

  • Item #: 11575402
  • MFR SKU: 475741-10MG
  • Overview A cell-permeable, blood-brain-barrier-permeant, and orally available carbamate compound that selectively inhibit MAGL (monoacylglycerol lipase) activity over FAAH (fatty acid amide hydrolase) and 35 other murine brain serine hydrolases, both in vitro (IC 50 = 6 - 8 nM against 2-AG hydrolysis by MAGL vs. 4 µ M against anandamide/AEA hydrolysis by FAAH) and in mice in vivo (5-fold 2-AG enhancement and 75% MAGL activity inhibition in brain membrane from mice 4 hr after a single JZL184 dosage at 4 mg/kg via i.p.) in an irreversible, time- and dose-dependent manner. A great complement to the FAAH inhibitor URB597 (Cat. No. 341249 ) in differentiating the roles of CB1 and CB2 (type I and II cannabinoid receptors) in eCB- (endocannabinoid) mediated cellular signaling and in vivo physiological effects. Reported to be equally effective against human and murine MAGL, but inhibit rat MAGL with a ~10-fold lower potency.
  • Catalogue Number 475741
  • Brand Family Calbiochem®
  • Synonyms 4-Nitrophenyl-4-(dibenzo[d][1, 3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184
  • References Nomura, D.K., et al. 2010. Cell 140, 49.
  • Long, J.Z., et al. Nature Chem. Biol. 16, 744.
  • Long, J.Z., et al. 2009. Nature Chem. Biol. 5, 37.
  • Pan, B., et al. 2009. J. Pharmacol. Exp. Ther. 331, 591.
  • CAS number 1101854-58-3
  • Form White to off-white solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Shipped with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.

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